You would have to place the heart in the equine body, there’s not enough space within the human chest without it vibrating and shaking all the time.
There’s a decent distance between the horse heart and the human head, though you’d likely need to have a super tough aorta and a series of valves within those blood vessels to regulate blood pressure to the head when it moves. Brains are very particular about how much blood pressure they like to function, and the giraffe is a pretty good real world model.
Would something like a ‘booster’ heart be a possibility? Maybe a small heart up where the human one would be? I know that’s not a thing that mammals have in our world, but I feel like it might be a decent approach to the problem.